Endocrine Abstracts

Osteoporosis is a major public health problem that is responsible for a considerable morbidity, mortality and health care costs. Evaluation of fracture risk is essential to select patients who will benefit most of interventional strategies. Most prospective cohort studies, with fracture outcomes, rely on participant self-report as the main or only source of information on fracture incidence. Systematic validation by screening of medical files is time-consuming, costly and almo...

Introduction: Osteoporosis is characterized by a low bone mass and a microarchiterctural disruption. Ageing and estrogen deficiency are the two most important factors for developing osteoporosis. With advanced age the balance between bone formation and resorption becomes progressively negative and non-bone factors contribute to the increased fracture risk with advancing age. Osteoporotic fractures constitute a major cause of morbidity and mortality in the elderly. Post-menopau...

In large population-based epidemiological studies of osteoporotic fractures, self-report is an important way of obtaining information. However, this method is subject to errors of recall and may result in misclassification of fracture status. Surprisingly, the accuracy of self-reported fractures has only rarely been assessed. The purpose of our study was to assess the accuracy of self-reported fractures in the FRISBEE cohort (Brussels, Belgium) of 3560 postmenopausal, aged 60&...